Dichloromethane → 4-(Azetidin-1-yl)piperidine-3-carboxamide

HRID 2316752Notes

Reaction equation

HRID 2316752 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([C:18]([NH2:19])=[O:20])[CH:11]([N:14]2[CH2:15][CH2:16][CH2:17]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:28][CH2:29][Cl:30].[F:21][C:22]([F:23])([F:24])[C:25]([OH:26])=[O:27]>>[NH:8]1[CH2:9][CH:10]([C:18]([NH2:19])=[O:20])[CH:11]([N:14]2[CH2:15][CH2:16][CH2:17]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 668703584-Azetidin-1-yl-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 668702684-(Azetidin-1-yl)piperidine-3-carboxamide

Sources & evidence

ORD record
ord-d54f725568d64b51ab4c67195d907b90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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