Methanol → 4-(6-Amino-5-(oxazolo[4,5-b]pyridin-2-yl)pyridin-3-yl)-2-methoxyphenol

HRID 2316755Notes

Reaction equation

HRID 2316755 reaction equation
[Br:19][c:20]1[cH:21][c:22](-[c:27]2[o:28][c:29]3[c:30]([n:31][cH:32][cH:33][cH:34]3)[n:35]2)[c:23]([NH2:26])[n:24][cH:25]1.[CH3:1][O:2][c:3]1[c:4]([OH:18])[cH:5][cH:6][c:7]([B:9]2[O:10][C:11]([CH3:12])([CH3:13])[C:14]([CH3:15])([CH3:16])[O:17]2)[cH:8]1.[CH3:38][OH:39].[Cs+:37].[F-:36].[Pd:40]([Cl:41])[Cl:42].[c:43]1([P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1>>[CH3:1][O:2][c:3]1[c:4]([OH:18])[cH:5][cH:6][c:7](-[c:20]2[cH:21][c:22](-[c:27]3[o:28][c:29]4[c:30]([n:31][cH:32][cH:33][cH:34]4)[n:35]3)[c:23]([NH2:26])[n:24][cH:25]2)[cH:8]1

Participants

8

Reactant 7

HCID 887MethanolHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 28179Fluoride IonHCID 104967Cesium cationHCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 673883775-Bromo-3-(oxazolo[4,5-b]pyridin-2-yl)pyridin-2-amine

Product 1

HCID 673884864-(6-Amino-5-(oxazolo[4,5-b]pyridin-2-yl)pyridin-3-yl)-2-methoxyphenol

Sources & evidence

ORD record
ord-c5f30bd730c947ed93fce63fe509cb7a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…