Imidazole → 5-(4-Bromo-phenyl)-4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazole

HRID 2317030Notes

Reaction equation

HRID 2317030 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH2:15][CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[OH:24])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1.[C:25]([CH3:26])([CH3:27])([CH3:28])[Si:29]([CH3:30])([CH3:31])[Cl:32].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[nH:33]1[cH:34][cH:35][n:36][cH:37]1>>[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH2:15][CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[O:24][Si:29]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:30])[CH3:31])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 665784451-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-ol

Product 1

HCID 665799345-(4-Bromo-phenyl)-4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazole

Sources & evidence

ORD record
ord-2ab39040b39340ada4aad67ff10d3a62
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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