3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid → HCID 131715999, compound

HRID 231749Notes

Reaction equation

HRID 231749 reaction equation
[CH3:1][C:2]1[C:20]([CH:21]([OH:23])[CH3:22])=[C:19]2[NH:24][C:3]=1[CH:4]=[C:5]1[C:38]([CH3:39])=[C:37]([CH2:40][CH2:41][C:42]([OH:44])=[O:43])[C:7]([CH:8]=[C:9]3[N:13]=[C:12]([CH:14]=[C:15]4[C:26]([CH:27]([OH:29])[CH3:28])=[C:25]([CH3:30])[C:17](=[CH:18]2)[NH:16]4)[C:11]([CH3:31])=[C:10]3[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[N:6]1>C1COCC1.C1CCC(NC2CCCCC2)CC1.CCOCC>[CH3:1][C:2]1[C:20]([CH:21]([OH:23])[CH3:22])=[C:19]2[NH:24][C:3]=1[CH:4]=[C:5]1[C:38]([CH3:39])=[C:37]([CH2:40][CH2:41][C:42]([OH:44])=[O:43])[C:7]([CH:8]=[C:9]3[N:13]=[C:12]([CH:14]=[C:15]4[C:26]([CH:27]([OH:29])[CH3:28])=[C:25]([CH3:30])[C:17](=[CH:18]2)[NH:16]4)[C:11]([CH3:31])=[C:10]3[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[N:6]1.[CH2:20]1[CH2:19][CH2:18][CH:17]([NH:16][CH:15]2[CH2:14][CH2:12][CH2:28][CH2:27][CH2:26]2)[CH2:25][CH2:30]1

Participants

5

Reactant 1

HCID 111033,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid

Product 1

HCID 131715999HCID 131715999, compoundYield 214.9%

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolvent2×HCID 7582DicyclohexylamineSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of hematoporphyrin (1 g) in THF (30 ml), DCHA (2 ml) dissolved in ether (10 ml) was added, whereby the reaction proceeded. Ether was added to the reaction mixture. The precipitated crystals were collected by filtration and washed with ether to give hematoporphyrin DCHA salt (1.4 g). Yield, 90.0%.

Workup

  1. additionwas added
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with ether

Sources & evidence

ORD record
ord-44ea4bb46a7b40638bd51bdfcae2b18c
Source dataset
uspto-grants-1989_07
Patent number
US04849207

Reaction notes

Loading…