2-Butenedioic acid → 3-(3,4-Difluorophenyl)-1-ethylpyrrolidin-3-ol
Reaction equation
[C:15](=[O:16])([O-:17])[O-:18].[CH3:32][OH:33].[CH3:34][C:35]#[N:36].[F:1][c:2]1[cH:3][c:4]([C:9]2([OH:14])[CH2:10][NH:11][CH2:12][CH2:13]2)[cH:5][cH:6][c:7]1[F:8].[I:21][CH2:22][CH3:23].[K+:19].[K+:20].[OH:24][C:25]([CH:26]=[CH:27][C:28](=[O:29])[OH:30])=[O:31]>>[F:1][c:2]1[cH:3][c:4]([C:9]2([OH:14])[CH2:10][N:11]([CH2:22][CH3:23])[CH2:12][CH2:13]2)[cH:5][cH:6][c:7]1[F:8]Participants
8
Sources & evidence
- ORD record
- ord-5d57ed321920479f9cfcc70390835c0c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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