Acetic Acid → N-Methyl-N-[(3S,4S)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 2317539Notes

Reaction equation

HRID 2317539 reaction equation
[CH2:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[N:12]1[CH2:13][CH:14]([N:19]([c:20]2[c:21]3[c:22]([n:23][cH:24][n:25]2)[nH:26][cH:27][cH:28]3)[CH3:29])[CH:15]([CH3:18])[CH2:16][CH2:17]1.[CH3:1][C:2](=[O:3])[OH:4].[CH:33]([OH:34])([CH3:35])[CH3:36].[H:30][H:31].[OH-:37].[OH-:39].[OH2:32].[Pd+2:38]>>[NH:12]1[CH2:13][CH:14]([N:19]([c:20]2[c:21]3[c:22]([n:23][cH:24][n:25]2)[nH:26][cH:27][cH:28]3)[CH3:29])[CH:15]([CH3:18])[CH2:16][CH2:17]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 961Hydroxide2×HCID 962WaterHCID 3776IsopropanolHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 12084829N-(1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 12084830N-Methyl-N-[(3S,4S)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-c92694b498d3465c8cb75354a2f81732
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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