HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → 6-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 3-(Piperazin-1-yl)propane-1,2-diol | HCID 111002 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinic acid | HCID 20032013 | — |
Reaction Steps
Operation was carried out in a manner similar to the one previously described in Example 5, using 1.6 g of 6-chloronicotinic acid and 3.2 g of 1-(2,3-dihydroxypropyl)piperazine in 50 ml dioxane. Grams 1.95 of 6-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinic acid were obtained, which, recrystallized from hot water, melted at 244°-246° C. (with decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849422 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-de6591fb4ff54debb2b99e294987e994 |
| Source note | uspto-grants-1989_07 |