反应详情

Operation was carried out in a manner similar to the one previously described in Example 5, using 1.6 g of 6-chloronicotinic acid and 3.2 g of 1-(2,3-dihydroxypropyl)piperazine in 50 ml dioxane. Grams 1.95 of 6-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinic acid were obtained, which, recrystallized from hot water, melted at 244°-246° C. (with decomposition).