1-(2-Hydroxyethyl)piperazine → HCID 20032003, compound

HRID 231768Notes

Reaction equation

HRID 231768 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:11]1[N:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>O1CCOCC1>[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:11]2[N:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 762582-Chloronicotinic acid

Product 1

HCID 20032003HCID 20032003, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Operation was carried out in a manner similar to the one previously described in Example 5, using 10.4 g of 1-(2-hydroxyethyl)piperazine and 6.3 g of 2-chloronicotinic acid in 100 ml dioxane under reflux for 18 hours. Grams 3.9 of 2-[4-(2-hydroxyethyl)piperazin-1-yl]nicotinic acid, melting at 148°-171° C. (with decomposition), were obtained.

Workup

  1. temperatureunder reflux for 18 hours

Sources & evidence

ORD record
ord-82f7302fd0904568ac211f5c81a51a50
Source dataset
uspto-grants-1989_07
Patent number
US04849422

Reaction notes

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