HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → 2-[4-(2-Hydroxyethyl)-1-piperazinyl]nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[4-(2-Hydroxyethyl)-1-piperazinyl]nicotinic acid | HCID 20032003 | — |
Reaction Steps
Operation was carried out in a manner similar to the one previously described in Example 5, using 10.4 g of 1-(2-hydroxyethyl)piperazine and 6.3 g of 2-chloronicotinic acid in 100 ml dioxane under reflux for 18 hours. Grams 3.9 of 2-[4-(2-hydroxyethyl)piperazin-1-yl]nicotinic acid, melting at 148°-171° C. (with decomposition), were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849422 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-82f7302fd0904568ac211f5c81a51a50 |
| Source note | uspto-grants-1989_07 |