Hydrogen Peroxide → HCID 14578922, compound

HRID 231785Notes

Reaction equation

HRID 231785 reaction equation
[Cl:1][C:2]1[C:7]2[S:8][CH2:9][CH2:10][C:11]3[C:12](=[N:13][N:14]([C:18]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=4)[C:15](=[O:17])[CH:16]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH:25]O.O>C(O)(=O)C>[Cl:1][C:2]1[C:7]2[S:8](=[O:25])[CH2:9][CH2:10][C:11]3[C:12](=[N:13][N:14]([C:18]4[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=4)[C:15](=[O:17])[CH:16]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14578897HCID 14578897, compound

Product 1

HCID 14578922HCID 14578922, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 0.9 g of 8-chloro-2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one, prepared in Example 24, in 20 ml of acetic acid is added 0.6 ml of 35% hydrogen peroxide with stirring at room temperature and the mixture is stirred for 18 hours at the same temperature. To the residue is added water, and the precipitated crystals are collected by filtration and repeatedly washed with ethanol to give 0.7 g of 8-chloro-2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide, melting at 217°-219° C. with decomposition.

Workup

  1. stirringthe mixture is stirred for 18 hours at the same temperature
  2. filtrationthe precipitated crystals are collected by filtration
  3. washrepeatedly washed with ethanol

Sources & evidence

ORD record
ord-15339fbfccb84d448178991e8fab7707
Source dataset
uspto-grants-1989_07
Patent number
US04849421

Reaction notes

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