Imidazole → HCID 10798573, compound

HRID 231787Notes

Reaction equation

HRID 231787 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[N:9]1([C:2]2[CH:7]=[C:6]([N:9]3[CH:13]=[CH:12][N:11]=[CH:10]3)[N:5]=[CH:4][N:3]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 709434,6-Dichloropyrimidine

Product 1

HCID 10798573HCID 10798573, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In anhydrous tetrahydrofuran, 298 mg of 4,6-dichloropyrimidine was substituted with 272 mg of imidazole. The reaction mixture was treated according to the procedure of Example 1 to yield 294 mg of 4,6-bis(1-imidazoly)pyrimidine, recrystallized from a mixture of isopropyl-alcohol and methanol, and having a melting point of 243°-244° C.

Workup

  1. additionThe reaction mixture was treated

Sources & evidence

ORD record
ord-624a60dbf6da4926bd6f3f3a2ff288ed
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

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