HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 10845857, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 2-Chloro-4-ethoxy-6-methylpyrimidine | HCID 15288671 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10845857 | HCID 10845857 | 50.5% |
Reaction Steps
In anhydrous tetrahydrofuran, 173 mg of 2-chloro-4-ethoxy-6-methylpyrimidine was substituted with 68 mg of imidazole. The reaction mixture was treated according to the procedure of Example 5 to yield 103 mg of 4-ethoxy-2-(1-imidazolyl)-6-methylpyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 115.5°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849424 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-ac4276e7b6eb4ada9ae53823912d360d |
| Source note | uspto-grants-1989_07 |