Imidazole → HCID 10845857, compound

HRID 231794Notes

Reaction equation

HRID 231794 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[C:4]([CH3:11])[N:3]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>O1CCCC1>[CH2:9]([O:8][C:6]1[CH:5]=[C:4]([CH3:11])[N:3]=[C:2]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[N:7]=1)[CH3:10]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 152886712-Chloro-4-ethoxy-6-methylpyrimidine

Product 1

HCID 10845857HCID 10845857, compoundYield 50.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In anhydrous tetrahydrofuran, 173 mg of 2-chloro-4-ethoxy-6-methylpyrimidine was substituted with 68 mg of imidazole. The reaction mixture was treated according to the procedure of Example 5 to yield 103 mg of 4-ethoxy-2-(1-imidazolyl)-6-methylpyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 115.5°-116° C.

Workup

  1. additionThe reaction mixture was treated

Sources & evidence

ORD record
ord-ac4276e7b6eb4ada9ae53823912d360d
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

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