Ammonium Hydroxide → HCID 10749494, compound

HRID 231803Notes

Reaction equation

HRID 231803 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:3]=1.[OH-].[NH4+:14]>C(Cl)Cl>[NH2:14][C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 106312394-Chloro-6-(1H-pyrazol-1-yl)pyrimidine

Product 1

HCID 10749494HCID 10749494, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In sealed tube, 180 mg of 6-chloro-4-(1-pyrazolyl)pyrimidine and 2.5 ml of concentrated ammonium hydroxide were warmed at 140° C. for 30 hours. The reaction mixture was dissolved in methylene chloride, and washed with water. The organic fraction was dried over anhydrous sodium sulfute, and distilled off. A residue was recrystallized from methanol to yield 148 mg of 6-amino-4-(1-pyrazolyl)pyrimidine, a flaking crystal having a melting point of 236.5°-237° C.,

Workup

  1. washwashed with water
  2. dry with materialThe organic fraction was dried over anhydrous sodium sulfute
  3. distillationdistilled off
  4. customA residue was recrystallized from methanol

Sources & evidence

ORD record
ord-6794ef1ee071485cb5ea3a94ed342816
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

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