Dimethylamine → HCID 22182618, compound

HRID 23181Notes

Reaction equation

HRID 23181 reaction equation
Cl[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:9](=[O:10])[O:8][CH2:7]2)=[O:3].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:9](=[O:10])[O:8][CH2:7]2)=[O:3]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 98155555-Chlorocarbonylphthalide

Product 1

HCID 22182618HCID 22182618, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-chlorocarbonylphthalid (32 g, 0.16 mole) in THF (300 ml) is added to dimethylamine (40% v/v in water, 300 ml) and ice (100 g). The mixture is stirred for 1 hour. THF is evaporated off in vacuo and precipitated crystals are filtred off at 5° C. and washed with water (100 ml).

Workup

  1. customTHF is evaporated off in vacuo
  2. customprecipitated crystals
  3. customare filtred off at 5° C.
  4. washwashed with water (100 ml)

Sources & evidence

ORD record
ord-877b7f1505ba404c8c115a7ea44af5ed
Source dataset
uspto-grants-2005_02
Patent number
US06849749B2

Reaction notes

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