Phosphorus oxychloride → HCID 14620586, compound

HRID 231818Notes

Reaction equation

HRID 231818 reaction equation
[CH3:1][O:2][C:3](=[O:28])[CH2:4][C:5]1[C:13]([CH2:14][C:15]([NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=2)=O)=[CH:12][C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=1.P(Cl)(Cl)(Cl)=O>>[CH3:1][O:2][C:3](=[O:28])[CH2:4][C:5]1[C:13]([CH2:14][C:15]2[C:25]3[C:20](=[CH:21][C:22]([O:26][CH3:27])=[CH:23][CH:24]=3)[CH2:19][CH2:18][N:17]=2)=[CH:12][C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 14620584HCID 14620584, compound

Product 1

HCID 14620586HCID 14620586, compound

Procedure

The title compound was prepared as described in Example 7 using 6-[2-[[2-(3-methoxyphenyl)ethyl]amino]-2-oxoethyl]-1,3-benzodioxole-5-acetic acid methyl ester (VIIIb) (7.71 g, 0.02 mole) and phosphorus oxychloride (7.66 g, 0.05 mole). The crystalline product that was obtained was recrystallized from acetonitrile. The product was amounted to 1.4 g (15%), and melted at 182°-184° dec.

Workup

  1. customThe crystalline product that was obtained
  2. customwas recrystallized from acetonitrile

Sources & evidence

ORD record
ord-37c83497c7fc4896849d04903864d10f
Source dataset
uspto-grants-1989_07
Patent number
US04849420

Reaction notes

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