Dimethyl Sulfoxide → Tert-butyl 4-(3-amino-4-nitrophenyl)piperazine-1-carboxylate

HRID 2318475Notes

Reaction equation

HRID 2318475 reaction equation
[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17](=[O:18])[N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1.[CH3:26][S:27]([CH3:28])=[O:29].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([NH2:8])[cH:7]1.[OH2:25]>>[c:2]1([N:22]2[CH2:21][CH2:20][N:19]([C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])[CH2:24][CH2:23]2)[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([NH2:8])[cH:7]1

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 742185-Chloro-2-nitroanilineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 22272542Tert-butyl 4-(3-amino-4-nitrophenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-d0eca4225b3d49ec9ac0e48f161e7eae
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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