Hydrochloric Acid → HCID 14515527, compound

HRID 231849Notes

Reaction equation

HRID 231849 reaction equation
[OH-].[K+].Cl.[CH2:4]([O:6][C:7]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[CH:10]=[C:9]([C:17]([O:19]CCC)=[O:18])[C:8]=1[C:23]1[C:28]([C:29]([O:31]C)=[O:30])=[CH:27][C:26]([O:33][CH3:34])=[C:25]2[O:35][CH2:36][O:37][C:24]=12)[CH3:5]>O1CCOCC1>[CH2:4]([O:6][C:7]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[CH:10]=[C:9]([C:17]([OH:19])=[O:18])[C:8]=1[C:23]1[C:28]([C:29]([OH:31])=[O:30])=[CH:27][C:26]([O:33][CH3:34])=[C:25]2[O:35][CH2:36][O:37][C:24]=12)[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14515526HCID 14515526, compound

Product 1

HCID 14515527HCID 14515527, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

In 4 ml of dioxane was dissolved in 48 mg of methyl 2-ethoxy-2',3'-methylenedioxy-6-propoxycarbonyl-3,4,4'-trimethoxy-1,1'-biphenyl-6'-carboxylate obtained in Example 9, and 1 ml of a 5% aqueous solution of potassium hydroxide was added to the solution. The mixture was heated at 70° C. and stirred overnight, the pH value was adjusted to 1 by 3N hydrochloric acid, and the mixture was extracted with chloroform. The solvent was removed from the extract to obtain 36 mg of 2-ethoxy-2',3'-methylenedioxy-3,4,4'-trimethoxy-1,1'-biphenyl-6,6'-dicarboxylic acid having the following physical properties (the yield was 86%).

Workup

  1. extractionthe mixture was extracted with chloroform
  2. customThe solvent was removed from the
  3. extractionextract

Sources & evidence

ORD record
ord-9f5250010efe4b76bf840703e544806c
Source dataset
uspto-grants-1989_07
Patent number
US04849448

Reaction notes

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