HCID 14502019, compound → HCID 20032094, compound

HRID 231861Notes

Reaction equation

HRID 231861 reaction equation
[CH2:1]([N:3]([CH2:24][CH3:25])[CH2:4][CH2:5][NH:6][CH:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11](=[O:18])[NH:10][C:9]2[C:19]([CH3:23])=[CH:20][CH:21]=[CH:22][C:8]1=2)[CH3:2].CO.[ClH:28]>CO>[ClH:28].[ClH:28].[NH2:10][C:9]1[C:19]([CH3:23])=[CH:20][CH:21]=[CH:22][C:8]=1[CH:7]1[C:13]2[C:12](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:11](=[O:18])[N:6]1[CH2:5][CH2:4][N:3]([CH2:24][CH3:25])[CH2:1][CH3:2]

Participants

4

Reactant 2

HCID 14502019HCID 14502019, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 20032094HCID 20032094, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.35 g of 11-(2-diethylaminoethylamino)-4-methyl-5, 11-dihydro-6H-dibenz[b,e]azepin-6 -one in 50 ml of methyl alcohol was added 5 ml of 3N-hydrogen chloride methyl alcohol solution. After stirring at room temperature for an hour, the reaction mixture was concentrated to dryness under reduced pressure. The obtained solid was tritylated with isopropyl ether and then separated by filtration to give 1.91 g of 3-(2-amino-3-methylphenyl)-2-(2-diethylaminoethyl)isoindolin-1one dihydrochloride 0.6 hydrate (Compound 25').

Workup

  1. concentrationthe reaction mixture was concentrated to dryness under reduced pressure
  2. customseparated by filtration

Sources & evidence

ORD record
ord-b2308581b9ca449f8ed34f1b8bc35684
Source dataset
uspto-grants-1989_07
Patent number
US04849441

Reaction notes

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