HCID 14502019, compound → HCID 20032094, compound

Participants

Reaction Steps

To a solution of 1.35 g of 11-(2-diethylaminoethylamino)-4-methyl-5, 11-dihydro-6H-dibenz[b,e]azepin-6 -one in 50 ml of methyl alcohol was added 5 ml of 3N-hydrogen chloride methyl alcohol solution. After stirring at room temperature for an hour, the reaction mixture was concentrated to dryness under reduced pressure. The obtained solid was tritylated with isopropyl ether and then separated by filtration to give 1.91 g of 3-(2-amino-3-methylphenyl)-2-(2-diethylaminoethyl)isoindolin-1one dihydrochloride 0.6 hydrate (Compound 25').

Provenance & Evidence