反应详情

25.0 g of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetic acid benzyl ester was dissolved in 500 ml of methanol and stirred at 40° C. with passing of gaseous NH3 for 5 hours. Then the reaction solution was evaporated and the residue was mixed with 50 ml of acetone. The precipitated crystals were filtered by suction and dried. 15.2 g of TLC pure product with a melting point of 174.5° to 175.5° C. was obtained. For the product:

1. customThen the reaction solution was evaporated
2. additionthe residue was mixed with 50 ml of acetone
3. filtrationThe precipitated crystals were filtered by suction
4. customdried
5. custom15.2 g of TLC pure product with a melting point of 174.5° to 175.5° C. was obtained