HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Benzyloxy-3-pyrrolin-2-on-1-yl acetic acid benzyl ester | HCID 14274471 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide | HCID 14274472 | — |
Reaction Steps
25.0 g of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetic acid benzyl ester was dissolved in 500 ml of methanol and stirred at 40° C. with passing of gaseous NH3 for 5 hours. Then the reaction solution was evaporated and the residue was mixed with 50 ml of acetone. The precipitated crystals were filtered by suction and dried. 15.2 g of TLC pure product with a melting point of 174.5° to 175.5° C. was obtained. For the product:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849528 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-1f8fe3bce16c4d26a5136cdd3c7c7eda |
| Source note | uspto-grants-1989_07 |