Tetrahydrofuran → Methyl 2',5'-difluoro-4-(hydroxymethyl)-1,1'-biphenyl-2-carboxylate

HRID 2318915Notes

Reaction equation

HRID 2318915 reaction equation
[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[F:1][c:2]1[c:3](-[c:9]2[c:10]([C:18](=[O:19])[O:20][CH3:21])[cH:11][c:12]([C:15](=[O:16])[OH:17])[cH:13][cH:14]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1>>[F:1][c:2]1[c:3](-[c:9]2[c:10]([C:18](=[O:19])[O:20][CH3:21])[cH:11][c:12]([CH2:15][OH:16])[cH:13][cH:14]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 577063522',5'-Difluoro-2-((methyloxy)carbonyl)-1,1'-biphenyl-4-carboxylic acid

Product 1

HCID 57705744Methyl 2',5'-difluoro-4-(hydroxymethyl)-1,1'-biphenyl-2-carboxylate

Sources & evidence

ORD record
ord-5e068d0c23b44ff7ba7cca44964fe038
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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