Hydrochloric Acid → HCID 14233598, compound

HRID 231901Notes

Reaction equation

HRID 231901 reaction equation
C([NH:4][C:5]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=O)C.Cl.[CH2:16](O)[CH3:17]>>[NH2:4][C:5]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:6]=1[C:7]([O:9][CH2:16][CH3:17])=[O:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 142335962-Acetamido-4-bromobenzoic acid

Product 1

HCID 14233598HCID 14233598, compoundYield 21%

Procedure

A solution of 119 g (0.461 mol) of 2-acetylamino-4-bromobenzoic acid and 3 liters of absolute ethanol was cooled to 0° C. and was then saturated with a stream of dry hydrogen chloride gas. The solution was then heated under reflux for 24 hours. Upon cooling to room temperature, the solution was evaporated to about 750 ml and then poured into 2 liters of aqueous saturated sodium bicarbonate. The aqueous phase was extracted three times with 300 ml portions of chloroform. The combined extracts were dried over anhydrous sodium sulfate, filtered, and evaporated to afford 23.8 g (21%) of ethyl 2-amino-4-bromobenzoate as an oil: ir(CHCl3) 3504 cm, 3390, 1685, 1610, 1580 among others; 1H-NMR(CDCl3) 1.3 ppm (triplet, 3H, CH2CH3), 4.3 (quartet, 2H, CH2CH3), 5.8 (broad singlet, 2H, NH2), 6.6 [doublet of AB pattern), 1H, aromatic H.], 6.8 (singlet, 1H, aromatic H), 7.7 [doublet (part of AB pattern), 1H, aromatic H].

Workup

  1. temperatureThe solution was then heated
  2. temperatureunder reflux for 24 hours
  3. customthe solution was evaporated to about 750 ml
  4. additionpoured into 2 liters of aqueous saturated sodium bicarbonate
  5. extractionThe aqueous phase was extracted three times with 300 ml portions of chloroform
  6. dry with materialThe combined extracts were dried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. customevaporated

Sources & evidence

ORD record
ord-ad500678b9074df7beee0e4e820b2690
Source dataset
uspto-grants-1989_07
Patent number
US04849518

Reaction notes

Loading…