HRID231945

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID180

Acetone

C3H6O

HCID222

Ammonia gas

H3N

HCID1146

Trimethylamine

C3H9N

结构：CCCCC(N)P(=O)(OC)O[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)N1CCC[C@H]1C(=O)OCC

HCID131716003

未命名化合物

结构：N#N.O=C(NCCCC[C@H](NC(=O)c1ccccc1)C(=O)O)OCc1ccccc1

HCID131716011

未命名化合物

PRODUCTS

生成物

结构：CCCCC(NC(=O)[C@H](CCCC)NC(=O)OC(C)(C)C)P(=O)(O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)OCC

HCID131716010

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Trimethylamine is bubbled into a solution of the diester product from part (a) (483 mg., 0.86 mmole) in acetone (6 ml.) according to the procedure of Example 4 part (f) to yield 432 mg. of 1-[(S)-2-[[[1-[[(S)-2-[[(1,1-dimethylethoxycarbonyl]amino]-1-oxohexyl]amino]pentyl]hydroxyphosphinyl]oxyl]-1-oxopropyl]-L-proline, ethyl ester (isomer B). TLC (silica gel; isopropanol:ammonia:water, 7:2:1) Rf =0.60.

WORKUP

后处理

customto yield 432 mg

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd1ac6a0e1e3482081438fa6c00764e7
来源数据集: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04849414
来源说明: uspto-grants-1989_07

反应 SMILES

[CH3:1]N(C)C.N#N.[C:7]([NH:15][C@H:16]([C:32](O)=[O:33])[CH2:17][CH2:18][CH2:19][CH2:20]NC(OCC1C=CC=CC=1)=O)(=[O:14])C1C=CC=CC=1.FC(F)(F)C(NCCC[CH2:43][C@H:44]([O:57][P:58]([CH:62]([NH2:67])[CH2:63][CH2:64][CH2:65][CH3:66])([O:60]C)=[O:59])[C:45]([N:47]1[CH2:56][CH2:55][CH2:54][C@H:48]1[C:49]([O:51][CH2:52][CH3:53])=[O:50])=[O:46])=O.N.[CH3:71][C:72]([CH3:74])=[O:73]>O.C(O)(C)C>[CH3:71][C:72]([CH3:1])([O:73][C:7]([NH:15][C@@H:16]([CH2:17][CH2:18][CH2:19][CH3:20])[C:32]([NH:67][CH:62]([P:58]([O:57][C@@H:44]([CH3:43])[C:45]([N:47]1[CH2:56][CH2:55][CH2:54][C@H:48]1[C:49]([O:51][CH2:52][CH3:53])=[O:50])=[O:46])([OH:60])=[O:59])[CH2:63][CH2:64][CH2:65][CH3:66])=[O:33])=[O:14])[CH3:74]