Dichloromethane → 3,4-Dihydro-2H-1,4-benzoxazine

HRID 2319589Notes

Reaction equation

HRID 2319589 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][cH:15][cH:16][cH:17]2)([CH3:5])([CH3:6])[CH3:7].[Cl:25][CH2:26][Cl:27].[OH:18][C:19]([C:20]([F:21])([F:22])[F:23])=[O:24]>>[NH:8]1[CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][cH:15][cH:16][cH:17]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 15348605Tert-butyl 2,3-dihydro-1,4-benzoxazine-4-carboxylate

Product 1

HCID 5850963,4-Dihydro-2H-1,4-benzoxazine

Sources & evidence

ORD record
ord-3b7ee7ef560f452b8538ae026c7f4ff6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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