反应详情

To 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide (0.45 g, 1.9 mmol) in ethanol (10 mL) was added 3-aminopropanol (0.72 mL, 9.4 mmol) (a compound of formula (Y9)). After heating the reaction in an oil bath at 60° C. for 1 day, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, washed with brine, dried (Na2SO4), and the solvent was removed in vacuo to give 0.44 g of 2-[(3-hydroxypropyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y10).

1. temperatureAfter heating
2. customthe reaction in an oil bath at 60° C. for 1 day
3. customthe reaction was partitioned with ethyl acetate and water
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried (Na2SO4)
7. customthe solvent was removed in vacuo