反应详情

Ethyl 2-cyanonicotinate (compound 2) (20 g; 0.113 mol) is added to a solution of potassium hydroxide (6 g; 0.017 mol) in distilled water (150 cc). The mixture is then allowed to stand for 10 hours at 25° C., and then washed with ether (2×50 cc). The aqueous solution is then evaporated to dryness to give compound 3 (19.1 g; m.p. 300° C.).

1. washwashed with ether (2×50 cc)
2. customThe aqueous solution is then evaporated to dryness