反应详情

Toluene (40 cc) containing compound 3 (4.1 g; 0.022 mol), ethyl bromoacetate (3.35 g; 0.02 mol) and TDA-1 (0.3 cc) is heated under reflux for 4 hours. The toluene is then evaporated off and the residue taken up with water and then extracted with dichloromethane. After drying, evaporating and crystallization in pentane, (ethoxycarbonyl)-methyl 2-cyanonicotinate (4.7 g; m.p. 74° C.) is obtained.

1. temperatureis heated
2. temperatureunder reflux for 4 hours
3. customThe toluene is then evaporated off
4. extractionextracted with dichloromethane
5. customAfter drying
6. customevaporating
7. customcrystallization in pentane