HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → (Ethoxycarbonyl)-methyl 2-cyanonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]- | HCID 112414 | — |
| Reactant | Potassium 2-cyanonicotinate | HCID 23690323 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (Ethoxycarbonyl)-methyl 2-cyanonicotinate | HCID 14050326 | 100.3% |
Reaction Steps
Toluene (40 cc) containing compound 3 (4.1 g; 0.022 mol), ethyl bromoacetate (3.35 g; 0.02 mol) and TDA-1 (0.3 cc) is heated under reflux for 4 hours. The toluene is then evaporated off and the residue taken up with water and then extracted with dichloromethane. After drying, evaporating and crystallization in pentane, (ethoxycarbonyl)-methyl 2-cyanonicotinate (4.7 g; m.p. 74° C.) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851396 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-08e313408e5e4fafa6beed1a00e4b047 |
| Source note | uspto-grants-1989_07 |