Diisopropylamine → HCID 20030583, compound

HRID 232015Notes

Reaction equation

HRID 232015 reaction equation
[C:1]([C:3]1[N:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6])#[N:2].[CH:12]([NH:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]>CC(C)=O>[C:1]([C:3]1[N:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([O-:7])=[O:6])#[N:2].[CH:12]([NH2+:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 7912DiisopropylamineHCID 125353152-Cyanopyridine-3-carboxylic acid

Product 1

HCID 20030583HCID 20030583, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Cyanonicotinic acid (0.74 g; 0.005 mol) suspended in acetone (40 cc) is treated with diisopropylamine (0.56 g; 0.0056 mol). The solvent is then evaporated off and the residue is crystallized in hexane: diisopropylammonium 2-cyanonicotinate (1.24 g; m.p. 156.7° C.) is obtained (yield=99%).

Workup

  1. customThe solvent is then evaporated off
  2. customthe residue is crystallized in hexane

Sources & evidence

ORD record
ord-aa3f32fd1b9d454e8391ba49a20f808d
Source dataset
uspto-grants-1989_07
Patent number
US04851396

Reaction notes

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