HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-(Pyrazol-1-yloxy)-propylphthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-hydroxy-1H-pyrazole | HCID 3016733 | — |
| Reactant | Bromopropylphthalimide | HCID 21958088 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-(Pyrazol-1-yloxy)-propylphthalimide | HCID 20030766 | 101.3% |
Reaction Steps
26 g of 1-hydroxypyrazole are added to a suspension of 10 g of sodium hydride (80 percent strength in oil) in 500 ml of xylene. The mixture is stirred for 1 hour, after which 84 g of 3-bromopropylphthalimide are added and the mixture is refluxed for 2 hours. After cooling, the mixture is filtered, the filtrate is evaporated down, the crystalline residue is suspended in diethyl ether and the product is filtered off under suction. 85 g of the title compound of melting point 116°-118° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851410 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-6b08d5eaf34d4792b1c35cff93a5f683 |
| Source note | uspto-grants-1989_07 |