反应详情

26 g of 1-hydroxypyrazole are added to a suspension of 10 g of sodium hydride (80 percent strength in oil) in 500 ml of xylene. The mixture is stirred for 1 hour, after which 84 g of 3-bromopropylphthalimide are added and the mixture is refluxed for 2 hours. After cooling, the mixture is filtered, the filtrate is evaporated down, the crystalline residue is suspended in diethyl ether and the product is filtered off under suction. 85 g of the title compound of melting point 116°-118° C. are obtained.

1. temperaturethe mixture is refluxed for 2 hours
2. temperatureAfter cooling
3. filtrationthe mixture is filtered
4. customthe filtrate is evaporated down
5. filtrationthe product is filtered off under suction