Dichloromethane → 6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

HRID 2320363Notes

Reaction equation

HRID 2320363 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([O:12][c:13]2[c:14]([O:36][CH3:37])[cH:15][c:16]([N:19]3[C:20](=[O:35])[c:21]4[c:22]([cH:25][c:26](-[c:28]5[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]5)[s:27]4)[CH2:23][CH2:24]3)[cH:17][cH:18]2)[CH2:11]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[NH:8]1[CH2:9][CH:10]([O:12][c:13]2[c:14]([O:36][CH3:37])[cH:15][c:16]([N:19]3[C:20](=[O:35])[c:21]4[c:22]([cH:25][c:26](-[c:28]5[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]5)[s:27]4)[CH2:23][CH2:24]3)[cH:17][cH:18]2)[CH2:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 689491773-{4-[2-(4-Chloro-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-2-methoxy-phenoxy}-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 689510906-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

Sources & evidence

ORD record
ord-6719430207c34905931f2e5e8a51054b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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