Ammonia → HCID 20031029, compound

HRID 232091Notes

Reaction equation

HRID 232091 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:10]=1)=O)C.[NH3:20]>CO>[F:19][C:13]1[C:14]([F:18])=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][N:9]1[CH:10]=[C:6]([C:4]([NH2:20])=[O:3])[N:7]=[CH:8]1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 54235425HCID 54235425, compound

Product 1

HCID 20031029HCID 20031029, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.34 g of 1-(2,3-difluorobenzyl)-imidazole-4-carboxylic acid ethyl ester are dissolved in 80 ml of methanol and transferred to an autoclave. 20.0 g of ammonia are introduced under pressure and the whole is heated at 100° for 19 hours. When the excess ammonia has been blown off, the resulting product is filtered off and recrystallised from ethanol. 1-(2,3-difluorobenzyl)-imidazole-4-carboxamide having a melting point of 221°-222° is obtained.

Workup

  1. temperaturethe whole is heated at 100° for 19 hours
  2. filtrationthe resulting product is filtered off
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-b280689a2e9d4a8081c31ecf41ea09c3
Source dataset
uspto-grants-1989_07
Patent number
US04851424

Reaction notes

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