Ammonia → HCID 20031029, compound

Participants

Reaction Steps

5.34 g of 1-(2,3-difluorobenzyl)-imidazole-4-carboxylic acid ethyl ester are dissolved in 80 ml of methanol and transferred to an autoclave. 20.0 g of ammonia are introduced under pressure and the whole is heated at 100° for 19 hours. When the excess ammonia has been blown off, the resulting product is filtered off and recrystallised from ethanol. 1-(2,3-difluorobenzyl)-imidazole-4-carboxamide having a melting point of 221°-222° is obtained.

Provenance & Evidence