HRID232110

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID10690

Gluconic acid

C6H12O7

$结构：CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1$

HCID2733526

Tamoxifen

C26H29NO

PRODUCTS

生成物

$结构：CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO$

HCID86743256

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A particular emulsion formulation such as a cream or lotion may be obtained for example, by adding a slurry of tamoxifen free base in ethanol or 2-propanol to an aqueous solution of D-gluconic acid to form tamoxifen gluconate in situ, which mixture is then combined with the required components of the disperse phase.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3a55d82677eb475d9abbec1a8bb2d0db
来源数据集: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04851433
来源说明: uspto-grants-1989_07

反应 SMILES

[CH3:1][CH2:2]/[C:3](/[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[C:4](/[C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])=[CH:15][CH:16]=1)\[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[O:29]=[C:30]([OH:41])[C@@H:31]([C@H:33]([C@@H:35]([C@@H:37]([CH2:39][OH:40])[OH:38])[OH:36])[OH:34])[OH:32]>C(O)C.CC(O)C>[CH3:1][CH2:2]/[C:3](/[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[C:4](/[C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])=[CH:15][CH:16]=1)\[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[O:29]=[C:30]([O-:41])[C@@H:31]([C@H:33]([C@@H:35]([C@@H:37]([CH2:39][OH:40])[OH:38])[OH:36])[OH:34])[OH:32]