Tetrahydrofuran → 6-[[2-(tert-butyl-dimethyl-silanyl)-3-methyl-3H-imidazol-4-yl]-(4-chloro-phenyl)-hydroxy-methyl]-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([c:6]1[n:7]([CH3:11])[cH:8][cH:9][n:10]1)([CH3:12])[CH3:13].[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH:14]([Li:15])([CH2:16][CH3:17])[CH3:18].[Cl:19][c:20]1[cH:21][cH:22][c:23]([C:24](=[O:25])[c:26]2[cH:27][c:28]3[c:29](-[c:41]4[cH:42][c:43]([Cl:47])[cH:44][cH:45][cH:46]4)[cH:30][c:31](=[O:40])[n:32]([CH2:36][CH:37]4[CH2:38][CH2:39]4)[c:33]3[cH:34][cH:35]2)[cH:48][cH:49]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([c:6]1[n:7]([CH3:11])[c:8]([C:24]([c:23]2[cH:22][cH:21][c:20]([Cl:19])[cH:49][cH:48]2)([OH:25])[c:26]2[cH:27][c:28]3[c:29](-[c:41]4[cH:42][c:43]([Cl:47])[cH:44][cH:45][cH:46]4)[cH:30][c:31](=[O:40])[n:32]([CH2:36][CH:37]4[CH2:38][CH2:39]4)[c:33]3[cH:34][cH:35]2)[cH:9][n:10]1)([CH3:12])[CH3:13]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-532ba4be9752411c89fd3422a6785990
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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