反应详情

A mixture of 80 mg of the Compound (10) obtained in Example 10, 131 mg of triphenylphosphine and 5 ml of carbon tetrachloride was heated under reflux for 4 hours in nitrogen streams. The solvent was evaporated off. The residue was subjected to a flash chromatograph using silica gel, followed by elution with hexane-ethyl acetate (1:2) to give 46 mg of the subject Compound (13) as colorless crystals, m.p. 50.5-51.0° C.

1. temperaturewas heated
2. temperatureunder reflux for 4 hours in nitrogen streams
3. customThe solvent was evaporated off
4. washfollowed by elution with hexane-ethyl acetate (1:2)