反应详情

In 16 ml of 1,2-dichloroethane was dissolved 0.40 g of the Compound (1) obtained in Example 1. To the solution was added 0.88 ml of thionyl chloride. The mixture was heated for 10 hours under reflux. The solvent was evaporated off, and the residue was subjected to a silica gel column chromatography, followed by elution with hexane-ethyl acetate (3:1) to give 0.36 g of the subject Compound (15) as colorless oil.

1. temperatureThe mixture was heated for 10 hours
2. temperatureunder reflux
3. customThe solvent was evaporated off
4. washfollowed by elution with hexane-ethyl acetate (3:1)