反应详情

In 8 ml of dichloromethane was suspended 110 mg of (4R)-4-phenylacetamido-3-isoxazolidinone. To the suspension were added, under ice-cooling and stirring, 0.14 ml of triethylamine and 2 ml of dichloromethane solution dissolving 106 mg of the Compound (27) obtained in Example (27). The reaction solution was stirred at room temperature for 40 minutes, washed with water and dried (Na2SO4). The solvent was then evaporated off. The residue was subjected to a silica gel column chromatography, followed by elution with hexane-ethyl acetate (2:3) to give 78 mg of the subject Compound (30) as colorless oil.

1. additionTo the suspension were added, under ice-
2. temperaturecooling
3. stirringThe reaction solution was stirred at room temperature for 40 minutes
4. washwashed with water
5. dry with materialdried (Na2SO4)
6. customThe solvent was then evaporated off
7. washfollowed by elution with hexane-ethyl acetate (2:3)