反应详情

In 20 ml of dichloromethane was suspended 1.00 g of 3-bromo-2-oxoglutaric acid. To the suspension was added 0.33 ml of ethane thiol under ice-cooling and stirring, to which was added 1.83 ml of triethylamine. The reaction solution was stirred at room temperature for 3 hours, then the solvent was evaporated off. The residue was shaken with a mixture of ethyl acetate and 1N-HCl. The ethyl acetate layer was taken, washed with water and dried (Na2SO4). The solvent was evaporated off to give 0.82 g of 3-ethylthio-2-oxoglutaric acid as pale yellow oil.

1. temperaturecooling
2. stirringThe reaction solution was stirred at room temperature for 3 hours
3. customthe solvent was evaporated off
4. stirringThe residue was shaken with a mixture of ethyl acetate and 1N-HCl
5. washwashed with water
6. dry with materialdried (Na2SO4)
7. customThe solvent was evaporated off