Trifluoroacetic acid → 5-Chloro-2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)benzo-thiophene

HRID 2322086Notes

Reaction equation

HRID 2322086 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:10]3([OH:17])[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]3)[s:9]2)[cH:18]1.[OH:19][C:20]([C:21]([F:22])([F:23])[F:24])=[O:25]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:10]3=[CH:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]3)[s:9]2)[cH:18]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 187973695-Chloro-2-(4-hydroxy-1-methylpiperidin-4-yl)benzothiophene

Product 1

HCID 187971665-Chloro-2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)benzo-thiophene

Sources & evidence

ORD record
ord-b9ef4b78f44c49bd9c78def1b79116f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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