反应详情

In 4 ml of 1,2-dichloroethane was dissolved 100 mg of the Compound 62 obtained in Example 62. To the solution was added 0.1 ml of thionyl chloride, and the mixture was heated for 4 hours under reflux. The solvent was evaporated off, then the residue was chromatographed on Florisil, followed by elution with hexane-ethyl acetate (2:1) to give 63 mg of the subject Compound (63) as pale yellow crystals.

1. temperaturethe mixture was heated for 4 hours
2. temperatureunder reflux
3. customThe solvent was evaporated off
4. customthe residue was chromatographed on Florisil
5. washfollowed by elution with hexane-ethyl acetate (2:1)