1,2-Dichloroethane → HCID 20030908, compound

HRID 232221Notes

Reaction equation

HRID 232221 reaction equation
[CH2:1]([CH:8]([C:25]([O-:27])=[O:26])[CH2:9][C:10](=O)[C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:28]CCCl>>[CH2:1]([CH:8]1[C:25](=[O:26])[O:27][C:10]([Cl:28])([C:11]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 111,2-DichloroethaneHCID 67902300HCID 67902300, compound

Product 1

HCID 20030908HCID 20030908, compound

Procedure

In 18 ml of 1,2-dichloroethane was dissolved 475 mg of the Compound (73) obtained in Example 73. The solution was heated for 5 hours under reflux. The solvent was evaporated off, and the residue was subjected to a column chromatography using Florisil, followed by elution with hexaneethyl acetate (5:1) to give 370 mg of the subject Compound (74) as a pale yellow oily product.

Workup

  1. temperatureThe solution was heated for 5 hours
  2. temperatureunder reflux
  3. customThe solvent was evaporated off
  4. washfollowed by elution with hexaneethyl acetate (5:1)

Sources & evidence

ORD record
ord-718b4647ae054e5dbe649ba66b708563
Source dataset
uspto-grants-1989_07
Patent number
US04851422

Reaction notes

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