反应详情

A 340 mg portion of the Compound (78) obtained in Example 78 was dissolved in 14 ml of 1,2-dichloroethane. To the solution was added 0.34 ml of thionyl chloride, and the mixture was heated for 5 hours under reflux. The solvent was evaporated off, and the residue was subjected to a column chromatography using Florisil, followed by elution with hexane-ethyl acetate (5:1) to give 152 mg of the subject Compound (79) as colourless oily product.

1. temperaturethe mixture was heated for 5 hours
2. temperatureunder reflux
3. customThe solvent was evaporated off
4. washfollowed by elution with hexane-ethyl acetate (5:1)