2-Oxoglutaric Acid → 5-n-Propylamino-4,5-dioxopentanoic acid

HRID 232228Notes

Reaction equation

[O:1]=[C:2]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[C:3]([OH:5])=O.[CH2:11]([NH2:14])[CH2:12][CH3:13]>>[CH2:11]([NH:14][C:3](=[O:5])[C:2](=[O:1])[CH2:6][CH2:7][C:8]([OH:10])=[O:9])[CH2:12][CH3:13]

Participants

Reactant 2

HCID 512-Oxoglutaric Acid

HCID 7852Propylamine

Product 1

HCID 143061155-n-Propylamino-4,5-dioxopentanoic acid

Procedure

Using 1.46 g of 2-oxoglutaric acid and 0.828 ml of n-propylamine, there was obtained 496 mg of the subject Compound (85), by conducting a reaction and treatment analogous to Example 83, as pale yellow crystals, m.p. 79°-81° C.

Sources & evidence

ORD record: ord-53ea0b53e5064048a9805cd0873af0fc
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851422

Reaction notes

Loading…