反应详情

In 15 ml of dichloroethane was dissolved 580 mg of Compound (97), followed by addition of 0.58 ml of thionyl chloride. The mixture was heated for one hour under reflux. The solvent was evaporated off, and the residue was treated with isopropylether to give 500 mg of the subject Compound (98) as colorless crystals, m.p. 132°-134° C.

1. temperatureThe mixture was heated for one hour
2. temperatureunder reflux
3. customThe solvent was evaporated off
4. additionthe residue was treated with isopropylether