Thionyl Chloride → HCID 20030930, compound

HRID 232231Notes

Reaction equation

HRID 232231 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:24])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:12])([OH:3])=O.S(Cl)([Cl:27])=O>ClC(Cl)C>[Cl:27][C:10]1([C:11]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:12])[C:5]2[C:4](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1](=[O:3])[O:24]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 86743267HCID 86743267, compound

Product 1

HCID 20030930HCID 20030930, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

In 15 ml of dichloroethane was dissolved 580 mg of Compound (97), followed by addition of 0.58 ml of thionyl chloride. The mixture was heated for one hour under reflux. The solvent was evaporated off, and the residue was treated with isopropylether to give 500 mg of the subject Compound (98) as colorless crystals, m.p. 132°-134° C.

Workup

  1. temperatureThe mixture was heated for one hour
  2. temperatureunder reflux
  3. customThe solvent was evaporated off
  4. additionthe residue was treated with isopropylether

Sources & evidence

ORD record
ord-89123cdad9c847ea8d5509cddc926a77
Source dataset
uspto-grants-1989_07
Patent number
US04851422

Reaction notes

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