反应详情

In 5 ml of dichloromethane were dissolved 236 mg of (4S)-4-benzyloxycarbonylamino-3-isoxazolidinone and 347 mg of Compound (98). To the solution was added, under ice-cooling, 0.14 ml of triethylamine, and the mixture was stirred for 30 minutes. The solvent was evaporated off. To the residue was added ethyl acetate, which was washed with water and an aqueous saline solution. The organic layer was dried, then the solvent was evaporated off. The residue was subjected to a column chromatography using Florisil, followed by elution with hexane--ethyl acetate (2:1→1:1) to give 350 mg of the subject Compound (99) as a pale yellow oily product.

1. additionTo the solution was added, under ice-
2. temperaturecooling
3. customThe solvent was evaporated off
4. additionTo the residue was added ethyl acetate, which
5. washwas washed with water
6. customThe organic layer was dried
7. customthe solvent was evaporated off
8. washfollowed by elution with hexane--ethyl acetate (2:1→1:1)